i405v and -629c/a polymorphisms of the cholesteryl ester transfer protein gene in patients with coronary artery disease

background: cholesteryl ester transfer protein (cetp) plays a main role in high-density lipoprotein metabolism. cetp gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (hdl-c) concentrations. the aim of this study was to determine the association of cetp -629c/a and i405v polymorphisms with coronary artery disease (cad) in iranian population. methods: the presence of two cetp gene polymorphisms -629c/a and i405v were studied in 187 unrelated cad cases and 136 controls. all the samples were clinically examined and lipid profile was estimated. genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. results: the frequency of -629c/a and i405v allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. the frequency of a allele of -629c/a polymorphism in cases was significantly higher than that of controls. hdl-c in aa genotype was higher than ca and cc genotypes in controls. no significant effect of ii, iv and vv genotypes was found in lipid profiles. conclusion: no significant association was found between cetp i405v polymorphism and increased risk of cad in azeri population studied. aa genotype of -629c/a increased hdl but the risk of cad in this genotype might be higher than cc genotype.